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OmniMist & NebSync Technology
August 2025 | IVPMED
OmniMist or NebSync Pulsating Nebulizers— What It Is?
Oral-cavity nebulizers that deliver hydrophilic formulations active as short, precisely timed aerosol pulses. It’s tuned for buccal/sublingual deposition (not deep lung), using a droplet size around 5–6 μm to coat the oral mucosa and enable rapid systemic uptake while minimizing swallow-through.
How the Pulsating Delivery Works
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Duty-cycled actuation: The ultrasonic mesh is driven in bursts (pulses) rather than continuously. Each pulse generates a brief “mist packet,” followed by a short pause.
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Film–renewal kinetics: The pause lets the mucosal surface absorb the deposited layer before the next pulse arrives, preventing pooling, runoff, and unnecessary swallowing
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Dose-per-pulse control: Pulse duration and frequency map directly to delivered mg, enabling reproducible micro-doses and programmable session recipes (e.g., 10×0.1s pulses).
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Targeted droplet size: ~5–6 μm droplets favor oropharyngeal/buccal deposition; smaller droplets (<3 μm) are more likely to reach the lungs, which Omnimist intentionally avoids for these actives.
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Thermal discipline: Pulsed drive minimizes continuous thermal load on the mesh and formulation, preserving peptide/nano-emulsion stability.
Why It’s Unique
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Oral-mucosa targeting by design
Most nebulizers are optimized for pulmonary delivery. Omnimist tunes droplet size, plume geometry, and pulse cadence for buccal/sublingual absorption, where many peptides perform best without injections
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Precise micro-dosing (mg-accurate) without needles
Duty cycle and pulse count create a direct, calibratable path from seconds → mg. That enables repeatable, low-mg peptide dosing that is hard to achieve with sprays or continuous foggers.
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Nano-emulsion compatibility
Built for 20–30 nm emulsions, supporting actives that benefit from mucosal permeation and protease shielding. Pulsed delivery reduces shear/heat exposure and limits coalescence versus long continuous runs.
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Reduced swallow-through, better bioavailability
By spacing pulses, Omnimist allows absorption windows between bursts, increasing the fraction absorbed via oral mucosa and reducing loss to the GI tract (first-pass metabolism).
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Session programmability
Pulse patterns (length, spacing, total pulses) can be tailored per active, e.g., fast onset peptides (ipamorelin/sermorelin) versus sustained cues (BPC-157/TB-500/Thymosin-α1)
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Clean, disposable fluid path
Amber (light-protective) cartridges and a disposable mesh path minimize cross-contamination, preserve light-sensitive actives, and simplify GMP workflows.
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System integration
Designed to tie into your connected dashboard for dose logging, lockouts, and remote updates—bridging consumer ease with clinical-grade traceability.
Benefits vs. Conventional Delivery Methods
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Versus oral tablets/capsules: Avoids GI degradation and first-pass metabolism; faster onset and lower required mg for many peptides.
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Versus nasal sprays: Similar speed without nasal irritation; larger allowable daily load without drip-through.
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Versus continuous nebulizers: Less runoff, less formulation stress, and more accurate mg control.
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Versus injections: Needle-free, user-friendly, and suitable for daily micro-dosing or pre-event bursts.​
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